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Editors contains: "Chan, Kin Foong"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, SPIE)
    Evans, Conor L; Chan, Kin Foong (Ed.)
    Pancreatic ductal adenocarcinoma continues to be one of the most lethal cancers today with an abysmal ~8% 5- year survival rate that has remained relatively constant over time. This is thought to be largely due the desmoplastic stroma in the extracellular matrix of these tumor types, inhibiting both the penetration as well as target engagement of treatments. Here we present a methodology for evaluating a monoclonal antibody’s drug target engagement in the presence of an extracellular matrix remodeling drug using paired-agent imaging principles and a subcutaneous tumor mouse model. 
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  2. ; ; ; ; ; ; ; ; (, Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII)
    Evans, Conor L.; Chan, Kin Foong (Ed.)
    Pancreatic ductal adenocarcinomas (PDACs) are often treatment resistant, and as such widefield imaging methods for the evaluation of ECM composition are needed. Here we present a method to measure the relative abundance of ECM diffracting components in PDAC samples alongside drug penetration in widefield images. Orthotopic mouse PDAC xenografts are grown and assessment of drug penetration as well as ECM composition is done using co-registration of scanning x-ray diffraction (XRD) and EGFR-specific drug penetration fluorescent widefield images. Preliminary data suggests a strongly negative correlation between abundance of diffracting ECM components and penetration of large drugs in solid tumors. This methodology may be used to provide crucial insights into both drug-development approaches and multi-therapeutic treatment strategies in late stage PDAC patients presenting with ECM desmoplasia. 
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  3. ; ; ; ; (, Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V)
    Evans, Conor L.; Chan, Kin Foong (Ed.)
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  4. ; ; ; ; ; ; ; ; ; (, Proceedings of SPIE)
    Evans, Conor L.; Chan, Kin Foong (Ed.)
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